Four Pillars of Containing Antimicrobial Resistance

Antibiotic_resistance_cartoonGlenn Tillotson, commenting on the Jim O’Neill report (1) in a short article in the Lancet Infectious Diseases has proposed additional frameworks to contain antimicrobial resistance. (2) The O’Neill report, titled “Review on antimicrobial resistance. Securing new drugs for future generations: the pipeline for antibiotics.”  is one of the most intensively researched documents into the emerging problem. Tillotson acknowledged the importance of the O’Neill report, stating:

“The latest report1 by Jim O’Neill and colleagues regarding the parlous state of antibiotic resistance and its effects—both financial and societal—has grabbed the bull by the horns and clearly stated the obvious, but essential, points of the economic reality of antibiotic development.”

Tillotson points out the four pillars on which the globally coordinated action plans need to be based on in order to make effective inroads into the problem of antimicrobial resistance. This is, unsurprisingly, in close alignment with the five strategic objectives identified by the WHO in the global action plan for antimicrobial resistance developed at the 68th World Health Assembly in May 2015.

The pillars proposed by Tillotson are:


Tillotson provides an insight into the difficulties in conducting research in the highly regulated environment that research today functions in and has stressed on horizontal integration of the vertically placed strategies for maximizing the benefits.


1. Review on antimicrobial resistance. Securing new drugs for future generations: the pipeline for antibiotics. Chaired by Jim O’Neill. May, 2015. Available from: LINK.

Tillotson G. Antimicrobial resistance: what’s needed. Lancet Infect Dis. 2015 Jul;15(7):758-60. doi: 10.1016/S1473-3099(15)00081-X. PubMed PMID: 26122435.


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